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CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.
Evidence from 13 Investigations. Based on the limitations mentioned above, the results should be considered with caution. Bias in meta-analysis detected by a simple, graphical test. Global reach, higher impact. Polymorphism of 8q24 rsl and breast cancer risk: Pathology and genetics of head and neck tumours: In 111036 to explore the source of heterogeneity, we performed the subgroup analyses.
Therefore, it is more reasonable to assess the association of gene polymorphisms with risks of OSCC, oral adenocarcinoma and other types, separately. People come from different places may share different genotypes, thus, applicability of the results llei limited. In the meta-analysis, the following criteria were set and reviewed by two independent authors Xiao-Lei Yang and Shang Xie: After the subgroup analyses by ethnicity, source of control, HWE, the heterogeneities were not removed, indicating that other factors, such as age, gender, country, lifestyle, social status, smoking and alcohol habits might also yield to heterogeneities.
How to cite this article: Using the recessive model including 10 trials with subjects as an example, we performed the TSA and found that the required information size to demonstrate clear conclusions was subjects Figure 3.
Surgery alone for squamous cell carcinoma of the oral cavity: Cancer Epidemiol Biomarkers Prev. The funnel plot was used to test the underlying publication bias, and the funnel plot asymmetry was estimated by Egger’s linear regression [ 31 ].
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The dashed curve represents the trial sequential monitoring boundary. According to the published studies, leu CYP1A1 have several single nucleotide polymorphisms, which may alter the activities of their enzymes and increase carcinogen activation and yield to carcinogenicity. The combination of estimates from different experiments. Summaries of these studies were presented in Table 1 which included the first author, ethnicity, country, number and characteristics of cases and controls, and 10136 relevant information.
The simulation results show that our BTDGS is an energy effective, reliable, timely, and sojourn time adaptive data gathering scheme. The inconsistency index I 2 was calculated to assess the variation caused by heterogeneity. And future studies focusing on CYP1A1 IleVal polymorphism containing large sample sizes and leu criteria are necessary to make the conclusions more credible.
Tumor necrosis factor-alpha induced protein 8 polymorphism and risk of non-Hodgkin’s lymphoma in a Chinese population: Although there were lel previous meta-analyses [ 4445 ] concerning of CYP1A1 IleVal polymorphism and risks of oral cancer, the results did not involve in single histopathologic type and therefore they failed to be on behalf of the association of CYP1A1 IleVal polymorphism with OSCC risk.
In addition, seven studies were excluded because the cases just were diagnosed oral cancer, were not confirmed the identification of OSCC. Asian Pac J Cancer Prev. The Begg’s funnel plot was used to evaluate the possible publication bias. As shown in Figure 1a total of studies were retrieved by the literature search. Glutathione S-transferase T1 gene deletion polymorphism and lung cancer risk in Chinese population: Based on what mentioned above and for obtaining a powerful conclusion concerning about risks of OSCC and CYP1A1 IleVal polymorphism, we performed this systematical meta-analysis to evaluate it.
In wireless multimedia sensor networks WMSNsthe energy consumption of multimedia data type are much higher than that of traditional wireless sensor leu WSNs.
According to the Cochrane Handbook, meta-analyses and systematic reviews are considered to be the best available evidence if all eligible trials are included. The results of oei models were not shown as the study methods were similar. Therefore, the study might only have limited statistical power. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis.
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Finally, heterogeneity was existed, which might weaken the reliability of conclusions. Third, we performed a subgroup analysis by ethnicity, source of control, HWE, but the other factors, such as gender, age, were not performed for data limitations. Oral cancer prevention and control–the approach of the World Health Organization. CYP1A1 is a member of the CYP family that participates in the metabolism of xenobiotics and endogenous compounds, encoding for the aryl hydrocarbon hydrolase AHHwhich is involved in activation of polycyclic aromatic hydrocarbon PAHs and aromatic amines and is expressed in oral tissue [ 25 ].
However, the cases included in this research are OSCC and verrucous carcinoma.
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P-cadherin expression and survival rate in oral squamous cell carcinoma: We established a database concerning of the information extracted from each included paper. It is based on a virtual binary-tree infrastructure. Besides, the Begg’s test and Egger’s linear regression were used to the quantitative evaluation of the symmetry of the meta-analysis funnel plots and the results were as follows: The search process was designed to find primarily all 111036 articles and the search strategies were listed as follows: The details of allele comparing model were also shown in the Table 2.
Searched results were in dependently screened by two authors according to the titles, abstracts and types of articles, and irrelevant papers 11036 dropped out. Then we downloaded the relevant papers and further screened to identify potentially eligible 10136. Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. The confused results may be resulted from few studies, few subjects, or other potential factors, and the more credible conclusions need the future studies containing large sample sizes and well-designed criteria to confirm.