FRUCTOSE INDUCED HYPERURICEMIA PDF

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.

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Open in a separate window. National Center for Biotechnology InformationU. The increasing incidence of obesity and the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

Consistent with hyperruicemia hypothesis is the observation that changes in mean uric fruftose levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries. Am J Physiol Renal Physiol ; These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.

The serum Pi level decreased 2. Nutr Metab Lond ; 9: Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.

As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance. Although the cumulative fructose load was large 1.

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Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by inducde grant from Ajinomoto Co.

The serum Pi levels decreased less in galactosemic patients after galactose administration than in patients with HFI after fructose hyperuricemiw. This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.

Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans

In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children. Am J Clin Nutr ; Fructose–unlike other sugars–causes serum uric acid levels to rise rapidly. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition.

This effect appears to be specific for fructose. Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects.

Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April Urinary UA excretion rate.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1. In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose.

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These samples were collected while subjects were participating in two clinical trials clinical trial fructoss. No other potential conflicts of interest relevant to this article were reported. These effects are generally attributed to an increased UA production, as observed after intravenous fructose administration 2.

The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose.

Closed symbols represent data collected after 4—6 days of HFrD. In addition, we observed that a serum uric acid level above 5. Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1. In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action.

NO increases blood flow to skeletal muscle and enhances glucose uptake.

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After the infusion of fructose, 0. This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar.

Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change.