Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.

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There is no exact formula for conversion from oral therapy to the decanoate; however, results from 1 study indicated that 20 mg fluphenazine hydrochloride orally daily was equivalent to 25 mg of fluphenazine decanoate every 3 weeks.

Extreme caution is recommended during concurrent use of other drugs that may lower the seizure threshold such as antipsychotics.

Those with known hypersensitivity to phenothiazines or who are predisposed to undue reactions should have therapy initiated with oral or immediate-release parenteral fluphenazine hydrochloride before receiving fluphenazine decanoate. This information is intended for use by health professionals.

There is no known effective treatment for tardive dyskinesia: Theoretically, these agents may increase the risk of QT prolongation if coadministered fluphenaazine drugs with a risk of QT prolongation. Major COMT inhibitors should be given cautiously with other agents that cause CNS depression, including phenothiazines, due to the possibility of additive sedation.

Co-administration of fluphenazine with atypical agents e. It is desirable to maintain as much flexibility in the dose as possible to achieve the best therapeutic response with the least side-effects; most patients are successfully maintained within the dose range 0.


Minor Phenothiazines may cause additive photosensitization with quinolones.

Modecate Injection 25mg/ml

Increased Mortality in Elderly people with Dementia. The administration of medicines containing benzyl alcohol as a preservative may cause toxic reactions and anaphylactoid reactions in children up to 3 years old. Patients with a history of suicidal ideation and who are at high risk for suicide attempt should be closely supervised pac,age initial drug therapy with fluphenazine.

Minor Androgen-deprivation therapy e. May cause additive effects of oversedation, respiratory depression, packagr hypotension. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: An ECG should also be performed at least 2, 12, and 24 weeks after starting bedaquiline therapy.

Increases plasma levels and toxicity.

Modecate Injection 25mg/ml – Summary of Product Characteristics (SmPC) – (eMC)

Major Concurrent use of MAOIs and phenothiazines may prolong or intensify the hypotensive, anticholinergic, or sedative effects of either agent. Increases risk of seizures. Coadministration of asenapine with phenothiazines may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures.

Moderate Monitor ECG for QT prolongation and monitor for additive sedation during concurrent use of lofexidine and fluphenazine. CNS depressants, including analgesics, barbiturates, narcotics, parenteral magnesium sulfate, tranquilizers, and general, spinal, or epidural anesthetics: Moderate Antipsychotics, such as phenothiazines, and methylphenidate may interact pharmacodynamically to diminish the therapeutic effects of either agent through f,uphenazine effects on dopamine.


Major The phenothiazines, when used concomitantly with anticonvulsants, can lower the seizure threshold. Fluphenazine is contraindicated in patients receiving large doses of hypnotics. Pharmaceutical form Solution for Injection Pale yellow clear, oily liquid.

The need to coadminister methadone with drugs known to prolong the QT interval should be done with extreme caution and a careful assessment of treatment risks versus benefits. Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate: If NMS is diagnosed, immediately discontinue deutetrabenazine, and provide intensive symptomatic treatment and medical monitoring.

Beta-blockers with greater renal elimination e. Antipsychotics may enhance the seizure risk of tramadol.

fluphenazine decanoate

Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes Pacckage. Because both fluphenazine and lithium have been associated with QT prolongation, coadminister cautiously and with close monitoring. Electrolyte imbalance, particularly hypokalaemia, greatly increases the risk of QT interval prolongation. Moderate Chlorpromazine, a phenothiazine, is associated with an established risk of QT prolongation and torsade de pointes TdP. Find out more here.

The syndrome is characterised by rhythmical involuntary movements of the tongue, face, mouth or jaw eg protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements.