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Chk s007 pdf

S1 Text Tables A-K indicating the main characteristics of included studies evaluating the impact of chemotherapy on different Schistosoma infection-related morbidities. Study characteristics Seventy-one eligible studies were abstracted from sixty-four papers.

The relative intensity of infection is an important correlate of morbidity, because the formation of the disease is related to the daily deposition of parasite eggs into host tissues [ 1748 — 50 ]. Thirteen studies evaluated school age children and three evaluated adult males. DOC Click here for additional data file.

For the sensitivity analysis, each meta-analysis was retested with the s0007 of one study at a time cjk assess the possibility of a disproportionate impact of any individual study on summary estimates. Immunopathogenesis of human schistosomiasis. This phenomenon thus limits the overall impact of drug treatment in communities at high risk for S. These new estimates may prove useful in cost-effectiveness estimations for program planning, and can provide direction for future operational research on treatment implementation strategies.

Quantifying heterogeneity in a meta-analysis.

Abstract Background SinceWHO has endorsed drug treatment to reduce Schistosoma infection and its consequent morbidity. The searches were conducted in August Significant heterogeneity was observed among the studies, which the subgroup analysis did not change significantly see Table H in S3 Text. The sensitivity testing indicated that the reduction in post treatment odds of periportal fibrosis likely varied between OR 0.

Forest plot showing sensitivity analysis, performed by removing one study at a time, for the effect of treatment on prevalence of periportal fibrosis PDF Click here for additional data file. ORs and their confidence intervals for individual studies are shown numerically in the statistics columns, and graphically by the corresponding black boxes and black lines.


In clinical studies, portal vein diameter is an indicator that correlates with portal vein pressure and risk for hemorrhage [ 47 ].

This article has been cited by other articles in PMC. Quantitative pooled analysis of treatment effects catalogued from the eligible studies was performed using Vhk Meta-Analysis software, v.

Reductions in right-sided hepatomegaly were also not significant for studies having a follow-up shorter than 12 months, or for individuals with S. Forest plot of the effect of anti-schistosomal treatment on hemoglobin levels. Post-treatment odds of splenomegaly and periportal fibrosis were not significantly reduced for infection with S.

The impact of Schistosoma japonicum infection and treatment on ultrasound-detectable morbidity: Our findings illuminate and help to quantify the magnitude of improvements after treatment of Schistosoma -associated morbidities.

CHK S pdf Datasheet P5 Part Num IC-ON-LINE

This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Chemotherapy-based control of schistosomiasis haematobia. Schistosomiasis and soil-transmitted helminthiases: Impact of repeated community-based selective chemotherapy on morbidity due to schistosomiasis mansoni. Our meta-analysis identified that significant gaps exist in the available literature on post-treatment reduction of morbidities. We assessed study quality using the National Heart, Lung, and Blood Institute quality assessment tools for pre-post design studies https: When considering all of these studies, there was significant reduction in the odds of having diarrhea after the intervention OR 0.

Forest plot z007 sensitivity analysis, performed by removing one study at a time, for the effect of treatment on prevalence of hepatomegaly lobe not specified. Significant heterogeneity was observed among the studies, which the subgroup analysis did not change see Table I in S3 Text.


However, the exclusion of one study with S. Chronic schistosomiasis is the form of infection that is predominant in endemic areas, which bear the greatest disease impact from long-lived Schistosoma infections [ 2 ].

The strength of association was higher as the follow-up time increased, unlike the results found in the lower urinary tract Table J in S3 Text. Sensitivity analysis Forest Plot of the impact of therapy on portal vein dilation prevalence.

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National Center for Biotechnology InformationU. Sensitivity analysis Forest Plot of the impact of therapy on urinary bladder abnormalities prevalence. In our summary estimates, only two morbidities showed no consistent or significant change between pre- and post-treatment surveys. Color circles indicate summary odds ratios estimated by random effects meta-analysis for morbidity prevalences after treatment, as compared to pre-treatment levels.

Meta-analysis and meta-regression are observational research that depends on the quality of the studies that are included.

Studies had to describe the study site, the species of Schistosoma parasite, the type of schistosomiasis morbidity evaluated before and after chemotherapy, the diagnostic method used to assess the morbidity, and the characteristics of participating study subject population. Three main factors yielded a larger estimate of the impact of therapy in reducing bladder lesions: To examine the hypothesis that post-treatment intensity of Schistosoma infection remains a correlate of morbidity risk after therapy, we performed meta-regression of the odds of having infection-related morbidities post-treatment as a function of post-treatment ERR achieved in an individual study population.

This was seen for the outcomes of hepatomegaly, diarrhea, periportal fibrosis, and abnormalities of the urinary bladder.