ANHIDRASA CARBONICA RENAL PDF

mato es una causa poco conocida de acidosis metabólica con anión restante normal; al inhibir la anhidrasa carbónica, se ocasiona una acido- sis tubular renal. therefore raised as to the level of the enzyme in the kidneys of premature infants. If the . La Anhidrasa Carbonica Renal en Prematuros y Niiios a Termino. Acidosis tubular renal inducida por topiramato. por su efecto inhibidor de la anhidrasa carbónica (renal y la localizada en neuroglía, mielina y plexo coroideo ).

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Carbonic anhydrase inhibitor

Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as anti- glaucoma agents, diureticsantiepilepticsin the management of mountain sicknessgastric and duodenal ulcers anhudrasa, idiopathic intracranial hypertensionneurological disordersor osteoporosis.

Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. They may also be used to treat seizure disorder and acute mountain sickness.

Because they encourage solubilization and excretion of uric acid, they can be used in the treatment of gout. Acetazolamide is an inhibitor of carbonic anhydrase. It is used for glaucoma, epilepsy rarelyidiopathic intracranial hypertensionand altitude sickness.

For the reduction of intraocular pressure IOPacetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP.

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Systemic effects include increased loss of sodium, potassium, and water in the urine, secondary to the drug’s effects on the renal tubuleswhere valuable components of filtered blood are re-absorbed in the kidney. Arterial Blood gases may show a mild hyperchloremic metabolic acidosis.

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Methazolamide is also a carbonic anhydrase inhibitor. It has a longer elimination half-life than acetazolamide and is less associated with adverse effects to the kidney. Dorzolamide is a carbonifa and topical carbonic anhydrase II inhibitor.

Carbonic anhydrase

It is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension and who are insufficiently responsive to beta-blockers.

Inhibition of carbonic anhydrase II in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Brinzolamide trade names Azopt, Alcon Laboratories, Inc, Befardin Fardi Medicals is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

The combination of brinzolamide with timolol is marketed under the trade name Azarga. Some diuretics [9] inhibit the activity of carbonic anhydrase in proximal convoluted tubules and prevent reabsorption of bicarbonates from renal tubules, resulting in osmotic diuresis.

Acetazolamide is a carbonic anhydrase inhibitor. Acetazolamide is effective in the treatment of most types of seizures, including generalized tonic-clonic and focal seizures and especially absence seizures, although it has limited utility because tolerance develops with chronic use.

The drug is occasionally used on an intermittent basis to prevent seizures in catamenial epilepsy. The sulfur-containing antiseizure and antimigraine drug topiramate is a weak inhibitor of carbonic anhydrase, particularly subtypes II and IV. In rare cases, the inhibition of carbonic anhydrase may be strong enough to cause metabolic acidosis of clinical importance. Zonisamide is another sulfur containing antiseizure drug that weakly inhibits carbonic anhydrase.

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At high altitude, the partial pressure of oxygen is lower and people have to breathe more rapidly to get adequate oxygen. When this happens, the partial pressure of CO2 in the lungs pCO2 decreases is “blown off”causing a respiratory alkalosis.

This would normally be compensated by the kidney excreting bicarbonate and causing compensatory metabolic acidosisbut this mechanism takes several days. A more immediate treatment is carbonic anhydrase inhibitors, which prevent bicarbonate uptake in the kidney and help correct the alkalosis. Loss of bicarbonate may result in metabolic acidosis. Ellagitannins extracted from the pericarps of Punica granatum rdnal, the pomegranate, such as punicalincarboincagranatin Bgallagyldilactonecasuarininpedunculagin and tellimagrandin Iare carbonic anhydrase inhibitors.

From Wikipedia, the free encyclopedia. Carbonic anhydrase inhibitor Drug class Acetazolamide. Expert Opinion on Therapeutic Patents. Neptazane Rmethazolamide. The Extra Pharmacopoeia electronic version. Cold Spring Renla Perspect Med. In Frost, Susan C. Experimental Biology and Medicine. New England Journal of Medicine. Competitive inhibition Uncompetitive inhibition Non-competitive inhibition Suicide inhibition Mixed ahhidrasa.

Drugs used for glaucoma preparations and miosis S01E. Retrieved from ” https: Wikipedia articles needing page number citations from May Template: Views Read Edit View history.

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In other projects Wikimedia Commons. This page was last edited on 24 Decemberat By using this site, you agree to the Terms of Use and Privacy Policy. Oxidoreductase EC 1 1. CA inhibitors at PT Acetazolamide.